A Pleiotropically Acting MicroRNA, miR-31, Inhibits Breast Cancer Metastasis
نویسندگان
چکیده
Scott Valastyan,1,2 Ferenc Reinhardt,1 Nathan Benaich,1,3 Diana Calogrias,4 Attila M. Szász,4 Zhigang C. Wang,5,6 Jane E. Brock,4 Andrea L. Richardson,4 and Robert A. Weinberg1,2,7,* 1Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA 2Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA 3Department of Biology, Williams College, Williamstown, MA 01267, USA 4Department of Pathology 5Department of Surgery Brigham and Women’s Hospital, Boston, MA 02115, USA 6Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA 7MIT Ludwig Center for Molecular Oncology, Cambridge, MA 02139, USA *Correspondence: [email protected] DOI 10.1016/j.cell.2009.03.047
منابع مشابه
Retraction Notice to: A Pleiotropically Acting MicroRNA, miR-31, Inhibits Breast Cancer Metastasis
MicroRNAs are well suited to regulate tumor metastasis because of their capacity to coordinately repress numerous target genes, thereby potentially enabling their intervention at multiple steps of the invasion-metastasis cascade. We identify a microRNA exemplifying these attributes, miR-31, whose expression correlates inversely with metastasis in human breast cancer patients. Overexpression of ...
متن کاملMicroRNA-33b Inhibits Breast Cancer Metastasis by Targeting HMGA2, SALL4 and Twist1
MicroRNAs are a class of small noncoding RNAs that regulate gene expression post-transcriptionally either by inhibiting protein translation or by causing the degradation of target mRNAs. Current evidence indicates that miR-33b is involved in the regulation of lipid metabolism, cholesterol homeostasis, glucose metabolism and several human diseases; however, whether miR-33b contributes to the pat...
متن کاملTumor suppression by miR-31 in esophageal carcinoma is p21-dependent
microRNA regulation network is important for the cancer genetic heterogeneity. Relative to the increasing numbers of microRNA's targets identified, upstream regulatory mechanisms that control functional microRNAs are less well-documented. Here, we investigated the function of miR-31, a pleiotropically-acting microRNA, in esophageal squamous cell cancer (ESCC). We demonstrated that miR-31 only e...
متن کاملMicroRNA-494 inhibits breast cancer progression by directly targeting PAK1
MicroRNA (miRNA) is involved in the progression and metastasis of diverse human cancers, including breast cancer, as strong evidence has been found that miRNAs can act as oncogenes or tumor suppressor genes. Here, we show that miR-494 is decreased in human breast cancer specimens and breast cancer cell lines. Ectopic expression of miR-494 in basal-like breast cancer cell lines MDA-MB-231-LUC-D2...
متن کاملMetastasis inhibition by BRMS1 and miR-31 replacement therapy in claudin-low cell lines
Objective(s): The growing trend of research demonstrates that dynamic expression of two metastasis repressor classes (metastasis suppressor genes and anti-metastatic miRNA) has a close relationship with tumor invasion and metastasis. Using different strategies, it was revealed that cellular levels of miR-31 and Breast cancer Metastasis Suppressor1 (BRMS1) protein, whic...
متن کامل